Ontology highlight
ABSTRACT:
SUBMITTER: Bellail AC
PROVIDER: S-EPMC4090607 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Bellail Anita C AC Olson Jeffrey J JJ Hao Chunhai C
Nature communications 20140623
Ubiquitination governs oscillation of cyclin-dependent kinase (CDK) activity through a periodic degradation of cyclins for orderly cell cycle progression; however, the mechanism that maintains the constant CDK protein levels throughout the cell cycle remains unclear. Here we show that CDK6 is modified by small ubiquitin-like modifier-1 (SUMO1) in glioblastoma, and that CDK6 SUMOylation stabilizes the protein and drives the cell cycle for the cancer development and progression. CDK6 is also a sub ...[more]