Ontology highlight
ABSTRACT:
SUBMITTER: Colis LC
PROVIDER: S-EPMC4090708 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Colis Laureen C LC Woo Christina M CM Hegan Denise C DC Li Zhenwu Z Glazer Peter M PM Herzon Seth B SB
Nature chemistry 20140511 6
The metabolite (-)-lomaiviticin A, which contains two diazotetrahydrobenzo[b]fluorene (diazofluorene) functional groups, inhibits the growth of cultured human cancer cells at nanomolar-picomolar concentrations; however, the mechanism responsible for the potent cytotoxicity of this natural product is not known. Here we report that (-)-lomaiviticin A nicks and cleaves plasmid DNA by a pathway that is independent of reactive oxygen species and iron, and that the potent cytotoxicity of (-)-lomaiviti ...[more]