Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes.
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ABSTRACT:
SUBMITTER: Lyn RK
PROVIDER: S-EPMC4091094 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes.
Lyn Rodney K RK Singaravelu Ragunath R Kargman Stacia S O'Hara Shifawn S Chan Helen H Oballa Renata R Huang Zheng Z Jones Daniel M DM Ridsdale Andrew A Russell Rodney S RS Partridge Anthony W AW Pezacki John Paul JP
Scientific reports 20140401
Hepatitis C virus (HCV) replication is dependent on the formation of specialized membrane structures; however, the host factor requirements for the formation of these HCV complexes remain unclear. Herein, we demonstrate that inhibition of stearoyl-CoA desaturase 1 (SCD-1) halts the biosynthesis of unsaturated fatty acids, such as oleic acid, and negatively modulates HCV replication. Unsaturated fatty acids play key roles in membrane curvature and fluidity. Mechanistically, we demonstrate that SC ...[more]
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