PEDF and PEDF-derived peptide 44mer protect cardiomyocytes against hypoxia-induced apoptosis and necroptosis via anti-oxidative effect.
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ABSTRACT:
SUBMITTER: Gao X
PROVIDER: S-EPMC4092347 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
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PEDF and PEDF-derived peptide 44mer protect cardiomyocytes against hypoxia-induced apoptosis and necroptosis via anti-oxidative effect.
Gao Xiao X Zhang Hao H Zhuang Wei W Yuan Guangda G Sun Teng T Jiang Xia X Zhou Zhongxin Z Yuan Honghua H Zhang Zhongming Z Dong Hongyan H
Scientific reports 20140711
Pigment epithelium-derived factor (PEDF) has many biological activities. But it's not known whether PEDF and its functional peptides could protect against hypoxia-induced cell death and the mechanisms are still unclear. We used cultured H9c2 cells and primary cardiomyocytes to show that apoptosis and necroptosis were significantly increased after hypoxia. Both PEDF and its fuctional peptides 44mer reduced apoptosis and necroptosis rates and inhibited the expression of cleaved caspase 3 and recep ...[more]
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