Ontology highlight
ABSTRACT:
SUBMITTER: Karabasheva D
PROVIDER: S-EPMC4094058 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20140602 28
Proteins targeted to the plasma membrane (PM) of cells are degraded at different rates. Sorting motifs contained within the cytoplasmic domains of transmembrane proteins, post-translational modifications (e.g. ubiquitination), and assembly into multiprotein or protein-lipid complexes all may affect the efficiency of endocytosis and recycling and influence the delivery to degradative compartments. Using the SNAP-tag labeling system, we examined the turnover of a model PM protein, the α chain of t ...[more]