Ontology highlight
ABSTRACT:
SUBMITTER: Vargas-Medrano J
PROVIDER: S-EPMC4094248 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Vargas-Medrano Javier J Krishnamachari Sesha S Villanueva Ernesto E Godfrey Wesley H WH Lou Haiyan H Chinnasamy Ramesh R Arterburn Jeffrey B JB Perez Ruth G RG
ACS medicinal chemistry letters 20140527 7
α-Synuclein is a chaperone-like protein implicated in Parkinson's disease (PD). Among α-synuclein's normal functions is an ability to bind to and stimulate the activity of the protein phosphatase 2A (PP2A) catalytic subunit in vitro and in vivo. PP2A activity is impaired in PD and in dementia with Lewy Bodies in brain regions harboring α-synuclein aggregates. Using PP2A as the readout, we measured PP2A activity in response to α-synuclein, ceramides, and FTY720, and then on the basis of those res ...[more]