Ontology highlight
ABSTRACT:
SUBMITTER: Cantley AM
PROVIDER: S-EPMC4094258 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Cantley Alexandra M AM Welsch Matthew M Ambesi-Impiombato Alberto A Sanchez-Martin Marta M Kim Mi-Yeon MY Bauer Andras A Ferrando Adolfo A Stockwell Brent R BR
ACS medicinal chemistry letters 20140425 7
Glucocorticoids are one of the most utilized and effective therapies in treating T-cell acute lymphoblastic leukemia. However, patients often develop resistance to glucocorticoids, rendering these therapies ineffective. We screened 9517 compounds, selected for their lead-like properties, chosen from among 3 372 615 compounds, against a dexamethasone-resistant T-ALL cell line to identify small molecules that reverse glucocorticoid resistance. We synthesized analogues of the most effective compoun ...[more]