Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium.
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ABSTRACT:
SUBMITTER: Loffredo FS
PROVIDER: S-EPMC4094348 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Publications
Heart failure with preserved ejection fraction: molecular pathways of the aging myocardium.
Loffredo Francesco S FS Nikolova Andriana P AP Pancoast James R JR Lee Richard T RT
Circulation research 20140601 1
Age-related diastolic dysfunction is a major factor in the epidemic of heart failure. In patients hospitalized with heart failure, HFpEF is now as common as heart failure with reduced ejection fraction. We now have many successful treatments for heart failure with reduced ejection fraction, while specific treatment options for HFpEF patients remain elusive. The lack of treatments for HFpEF reflects our very incomplete understanding of this constellation of diseases. There are many pathophysiolog ...[more]
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Project description:To understand the cellular mechanisms of heart failure with preserved ejection fraction (HFpEF), We investigated the functional outcome and the underlying mechanisms from concurrent mechanic and metabolic stresses in the heart by applying transverse aortic constriction (TAC) in lean C57Bl/6J (HFrEF phenotype) or obese/diabetic B6.Cg-Lepob/J (ob/ob) mice (HFpEF phenotype) followed by single-nuclei RNA-seq (snRNA-seq) and targeted manipulation of a top ranked signaling pathway (glucagon receptor signaling) differentially affected in the two experimental cohorts.
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