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Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

ABSTRACT: INTRODUCTION: We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE. METHODS: Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. Genetic risk load was calculated as sex-specific sum genetic risk scores (GRS(s)). RESULTS: Our results did not replicate those of the previous study at either the level of individual loci or the global level of GRS(s). GRS(s) were larger in women than in men (4.20?±?1.07 in women vs. 3.27?±?0.98 in men). This very significant difference (P?

SUBMITTER: Alonso-Perez E

PROVIDER: S-EPMC4095681 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

Alonso-Perez Elisa E Suarez-Gestal Marian M Calaza Manuel M Blanco Francisco J FJ Suarez Ana A Santos Maria Jose MJ Papasteriades Chryssa C Carreira Patricia P Pullmann Rudolf R Ordi-Ros Josep J Marchini Maurizio M Skopouli Fotini N FN Bijl Marc M Barrizone Nadia N Sebastiani Gian Domenico GD Migliaresi Sergio S Witte Torsten T Lauwerys Bernard R BR Kovacs Attila A Ruzickova Sarka S Gomez-Reino Juan J JJ Gonzalez Antonio A

Arthritis research & therapy 20140619 3

<h4>Introduction</h4>We aimed to replicate a recent study which showed higher genetic risk load at 15 loci in men than in women with systemic lupus erythematosus (SLE). This difference was very significant, and it was interpreted as indicating that men require more genetic susceptibility than women to develop SLE.<h4>Methods</h4>Nineteen SLE-associated loci (thirteen of which are shared with the previous study) were analyzed in 1,457 SLE patients and 1,728 healthy controls of European ancestry. ...[more]

PMID: 24946689

Dataset Information

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

Publications

Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.

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