Ontology highlight
ABSTRACT:
SUBMITTER: Leioatts N
PROVIDER: S-EPMC4096112 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Leioatts Nicholas N Mertz Blake B Martínez-Mayorga Karina K Romo Tod D TD Pitman Michael C MC Feller Scott E SE Grossfield Alan A Brown Michael F MF
Biochemistry 20140108 2
Rhodopsin, the mammalian dim-light receptor, is one of the best-characterized G-protein-coupled receptors, a pharmaceutically important class of membrane proteins that has garnered a great deal of attention because of the recent availability of structural information. Yet the mechanism of rhodopsin activation is not fully understood. Here, we use microsecond-scale all-atom molecular dynamics simulations, validated by solid-state (2)H nuclear magnetic resonance spectroscopy, to understand the tra ...[more]