Ontology highlight
ABSTRACT:
SUBMITTER: Turlington M
PROVIDER: S-EPMC4096224 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20140625 13
Positive allosteric modulators (PAMs) of metabotropic glutamate receptor 5 (mGlu5) represent a promising therapeutic strategy for the treatment of schizophrenia. Starting from an acetylene-based lead from high throughput screening, an evolved bicyclic dihydronaphthyridinone was identified. We describe further refinements leading to both dihydronaphthyridinone and tetrahydronaphthyridine mGlu5 PAMs containing an alkoxy-based linkage as an acetylene replacement. Exploration of several structural f ...[more]