Ontology highlight
ABSTRACT:
SUBMITTER: Liehl P
PROVIDER: S-EPMC4096771 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Nature medicine 20131222 1
Before they infect red blood cells and cause malaria, Plasmodium parasites undergo an obligate and clinically silent expansion phase in the liver that is supposedly undetected by the host. Here, we demonstrate the engagement of a type I interferon (IFN) response during Plasmodium replication in the liver. We identified Plasmodium RNA as a previously unrecognized pathogen-associated molecular pattern (PAMP) capable of activating a type I IFN response via the cytosolic pattern recognition receptor ...[more]