Exocyst complex protein expression in the human placenta.

ABSTRACT:

Introduction

Protein production and secretion are essential to syncytiotrophoblast function and are associated with cytotrophoblast cell fusion and differentiation. Syncytiotrophoblast hormone secretion is a crucial determinant of maternal-fetal health, and can be misregulated in pathological pregnancies. Although, polarized secretion is a key component of placental function, the mechanisms underlying this process are poorly understood.

Objective

While the octameric exocyst complex is classically regarded as a master regulator of secretion in various mammalian systems, its expression in the placenta remained unexplored. We hypothesized that the syncytiotrophoblast would express all exocyst complex components and effector proteins requisite for vesicle-mediated secretion more

SUBMITTER: Gonzalez IM 

PROVIDER: S-EPMC4096856 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature