Ontology highlight
ABSTRACT:
SUBMITTER: Fan QH
PROVIDER: S-EPMC4096895 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Organic & biomolecular chemistry 20140501 17
Experimental evidence is provided for p-methylbenzyl-D-galactonoamidine to function as a true transition state analog for the enzymatic hydrolysis of aryl-β-D-galactopyranosides by β-galactosidase (A. oryzae). The compound exhibits inhibition constants in the low nanomolar concentration range (12-56 nM) for a selection of substrates. Along these lines, a streamlined synthetic method based on phase-transfer catalysis was optimized to afford the required variety of new aryl-β-D-galactopyranosides. ...[more]