Chemotherapy regimens for advanced pancreatic cancer: a systematic review and network meta-analysis.

ABSTRACT:

Background

Advanced pancreatic cancer confers poor prognosis and treatment advancement has been slow. Recent randomized clinical trials (RCTs) have demonstrated survival benefits for combination therapy compared to gemcitabine alone. However, the comparative benefits and harms of available combination chemotherapy treatments are not clear. We therefore conducted a systematic review and Bayesian network meta-analysis to assess the comparative safety and efficacy of chemotherapy regimens for the treatment of advanced pancreatic cancer.

Methods

MEDLINE, PubMed, EMBASE, Cochrane Central Registry of Clinical trials and abstracts from major scientific meetings were searched for RCTs published from 2002 to 2013. Key outcomes were overall survival (OS), progression free survival (PF

SUBMITTER: Gresham GK 

PROVIDER: S-EPMC4097092 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature