AMPA receptor subunits expression and phosphorylation in cingulate cortex in rats following esophageal acid exposure.

ABSTRACT:

Background

We recently reported an increase in N-methyl-d-aspartate (NMDA) receptor subunit expression and CaMKII-dependent phosphorylation of NR2B in the rostral cingulate cortical (rCC) neurons following esophageal acid exposure in rats. As α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate the fast excitatory transmission and play a critical role in synaptic plasticity, in this study, we investigated the effect of esophageal acid exposure in rats on the expression of AMPA receptor subunits and the involvement of these molecular alterations in acid-induced sensitization of neurons in the anterior cingulate (ACC) and midcingulate (MCC) cortices.

Methods

In molecular study, we examined GluA1 and GluA2 expression and phosphorylation in membrane pre

SUBMITTER: Banerjee B 

PROVIDER: S-EPMC4097166 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature