Ontology highlight
ABSTRACT:
SUBMITTER: Schneider JS
PROVIDER: S-EPMC4097585 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Schneider Jessica S JS Sklar Joseph G JG Glickman Michael S MS
Journal of bacteriology 20140509 14
Regulated intramembrane proteolysis of membrane-embedded substrates by site-2 proteases (S2Ps) is a widespread mechanism of transmembrane signal transduction in bacteria and bacterial pathogens. We previously demonstrated that the Mycobacterium tuberculosis S2P Rip1 is required for full virulence in the mouse model of infection. Rip1 controls transcription in part through proteolysis of three transmembrane anti-sigma factors, anti-SigK, -L, and -M, but there are also Rip1-dependent, SigKLM-indep ...[more]