In silico designing and molecular docking of a potent analog against Staphylococcus aureus porphobilinogen synthase.

ABSTRACT:

Background

The emergence of multidrug-resistant strains of Staphylococcus aureus, there is an urgent need for the development of new antimicrobials which are narrow and pathogen specific.

Aim

In this context, the present study is aimed to have a control on the staphylococcal infections by targeting the unique and essential enzyme; porphobilinogen synthase (PBGS) catalyzes the condensation of two molecules of δ-aminolevulinic acid, an essential step in the tetrapyrrole biosynthesis. Hence developing therapeutics targeting PBGS will be the promising choice to control and manage the staphylococcal infections. 4,5-dioxovalerate (DV) is known to inhibit PBGS.

Materials and methods

In view of this, in this study, novel dioxovalerate derivatives (DVDs) molecules were designe

SUBMITTER: Kumar PS 

PROVIDER: S-EPMC4097929 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature