High-sensitivity cardiac troponin T and cognitive function and dementia risk: the atherosclerosis risk in communities study.

ABSTRACT:

Aim

Clinical cardiovascular disease is a major risk factor for cognitive impairment and dementia. However, less is known about the association of subclinical myocardial damage with cognition and dementia. We sought to examine the associations of high-sensitivity cardiac troponin T (hs-cTnT) with cognition and dementia.

Methods and results

Cross-sectional analysis of cognition (baseline 1996-98) and prospective analysis of dementia (follow-up through 2010) in 9472 participants in the Atherosclerosis Risk in Communities study. High-sensitivity cardiac troponin T was measured using a novel highly sensitive assay with a lower limit of the blank of 3 ng/L. Cognitive function was assessed by three tests: the delayed word recall test (DWRT), the digit symbol substitution test (DSST

SUBMITTER: Schneider AL 

PROVIDER: S-EPMC4097965 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature