Ontology highlight
ABSTRACT:
SUBMITTER: Luptakova K
PROVIDER: S-EPMC4098790 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Luptakova Katarina K Rosenblatt Jacalyn J Glotzbecker Brett B Mills Heidi H Stroopinsky Dina D Kufe Turner T Vasir Baldev B Arnason Jon J Tzachanis Dimitri D Zwicker Jeffrey I JI Joyce Robin M RM Levine James D JD Anderson Kenneth C KC Kufe Donald D Avigan David D
Cancer immunology, immunotherapy : CII 20120624 1
Lenalidomide is an effective therapeutic agent for multiple myeloma that exhibits immunomodulatory properties including the activation of T and NK cells. The use of lenalidomide to reverse tumor-mediated immune suppression and amplify myeloma-specific immunity is currently being explored. In the present study, we examined the effect of lenalidomide on T-cell activation and its ability to amplify responses to a dendritic cell-based myeloma vaccine. We demonstrate that exposure to lenalidomide in ...[more]