Ontology highlight
ABSTRACT:
SUBMITTER: Jung ME
PROVIDER: S-EPMC4099047 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
The Journal of organic chemistry 20121128 23
Oxidative cleavage of cycloalkene-1-carboxylates, made from the corresponding carboxylic acids, and subsequent oxidation of the resulting ketoaldehyde afforded the important 1-monoesters of 2-ketoalkanedioic acids. Thus ozonolysis of octyl cyclobutene-1-carboxylate followed by sodium chlorite oxidation afforded the 1-monooctyl 2-ketoglutarate. This is a cell-permeable prodrug form of α-ketoglutarate, an important intermediate in the tricarboxylic acid (TCA, Krebs) cycle and a promising therapeut ...[more]