Ontology highlight
ABSTRACT:
SUBMITTER: Sanchez R
PROVIDER: S-EPMC4099289 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Sanchez Roberto R Meslamani Jamel J Zhou Ming-Ming MM
Biochimica et biophysica acta 20140328 8
Lysine acetylation is a fundamental post-translational modification that plays an important role in the control of gene transcription in chromatin in an ordered fashion. The bromodomain, the conserved structural module present in transcription-associated proteins, functions exclusively to recognize acetyl-lysine on histones and non-histone proteins. The structural analyses of bromodomains' recognition of lysine-acetylated peptides derived from histones and cellular proteins provide detailed insi ...[more]