Ontology highlight
ABSTRACT:
SUBMITTER: Dahlhoff C
PROVIDER: S-EPMC4099513 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Dahlhoff Christoph C Worsch Stefanie S Sailer Manuela M Hummel Björn A BA Fiamoncini Jarlei J Uebel Kirsten K Obeid Rima R Scherling Christian C Geisel Jürgen J Bader Bernhard L BL Daniel Hannelore H
Molecular metabolism 20140520 5
Non-alcoholic fatty liver disease (NAFLD) results from increased hepatic lipid accumulation and steatosis, and is closely linked to liver one-carbon (C1) metabolism. We assessed in C57BL6/N mice whether NAFLD induced by a high-fat (HF) diet over 8 weeks can be reversed by additional 4 weeks of a dietary methyl-donor supplementation (MDS). MDS in the obese mice failed to reverse NAFLD, but prevented the progression of hepatic steatosis associated with major changes in key hepatic C1-metabolites, ...[more]