The Nogo receptor NgR1 mediates infection by mammalian reovirus.
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ABSTRACT:
SUBMITTER: Konopka-Anstadt JL
PROVIDER: S-EPMC4100558 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
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The Nogo receptor NgR1 mediates infection by mammalian reovirus.
Konopka-Anstadt Jennifer L JL Mainou Bernardo A BA Sutherland Danica M DM Sekine Yuichi Y Strittmatter Stephen M SM Dermody Terence S TS
Cell host & microbe 20140601 6
Neurotropic viruses, including mammalian reovirus, must disseminate from an initial site of replication to the central nervous system (CNS), often binding multiple receptors to facilitate systemic spread. Reovirus engages junctional adhesion molecule A (JAM-A) to disseminate hematogenously. However, JAM-A is dispensable for reovirus replication in the CNS. We demonstrate that reovirus binds Nogo receptor NgR1, a leucine-rich repeat protein expressed in the CNS, to infect neurons. Expression of N ...[more]
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