Ontology highlight
ABSTRACT:
SUBMITTER: Li C
PROVIDER: S-EPMC4100753 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Li Chang C Xu Xiaofei X Wang Xiu Jun XJ Pan Yuanjiang Y
PloS one 20140716 7
Resveratrol is a natural phenol with protective effects against cancer and inflammation-related diseases. Its mechanism of action involves the activation of nuclear factor E2 p45-related factor 2 (Nrf2), which plays a key role in regulation of genes driven by antioxidant response element (ARE). Inspired by the effect of resveratrol, here we synthesized a series of imine resveratrol analogs (IRAs), evaluated their abilities to activate Nrf2 by using cell based ARE-reporter assay. After the first- ...[more]