Ontology highlight
ABSTRACT:
SUBMITTER: Wan L
PROVIDER: S-EPMC4101059 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Wan Liling L Lu Xin X Yuan Salina S Wei Yong Y Guo Feng F Shen Minhong M Yuan Min M Chakrabarti Rumela R Hua Yuling Y Smith Heath A HA Blanco Mario Andres MA Chekmareva Marina M Wu Hao H Bronson Roderick T RT Haffty Bruce G BG Xing Yongna Y Kang Yibin Y
Cancer cell 20140626 1
The Metadherin gene (MTDH) is prevalently amplified in breast cancer and associated with poor prognosis; however, its functional contribution to tumorigenesis is poorly understood. Using mouse models representing different subtypes of breast cancer, we demonstrated that MTDH plays a critical role in mammary tumorigenesis by regulating oncogene-induced expansion and activities of tumor-initiating cells (TICs), whereas it is largely dispensable for normal development. Mechanistically, MTDH support ...[more]