Ontology highlight
ABSTRACT:
SUBMITTER: Hilder TA
PROVIDER: S-EPMC4101527 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Hilder Tamsyn A TA Ridone Pietro P Nakayama Yoshitaka Y Martinac Boris B Chung Shin-Ho SH
Scientific reports 20140717
Multi-drug resistance is becoming an increasing problem in the treatment of bacterial infections and diseases. The mechanosensitive channel of large conductance (MscL) is highly conserved among prokaryotes. Evidence suggests that a pharmacological agent that can affect the gating of, or block the current through, MscL has significant potential as a new class of antimicrobial compound capable of targeting a range of pathogenic bacteria with minimal side-effects to infected patients. Using molecul ...[more]