Ontology highlight
ABSTRACT:
SUBMITTER: Boutin A
PROVIDER: S-EPMC4101659 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Boutin Alisa A Eliseeva Elena E Gershengorn Marvin C MC Neumann Susanne S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140410 8
Thyrotropin (TSH) activation of the TSH receptor (TSHR), a 7-transmembrane-spanning receptor (7TMR), may have osteoprotective properties by direct effects on bone. TSHR activation by TSH phosphorylates protein kinases AKT1, p38α, and ERK1/2 in some cells. We found TSH-induced phosphorylation of these kinases in 2 cell lines engineered to express TSHRs, human embryonic kidney HEK-TSHR cells and human osteoblastic U2OS-TSHR cells. In U2OS-TSHR cells, TSH up-regulated pAKT1 (7.1±0.5-fold), p38α (2. ...[more]