Ontology highlight
ABSTRACT:
SUBMITTER: Zhu J
PROVIDER: S-EPMC4101812 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Zhu Jianzhong J Zhang Yugen Y Ghosh Arundhati A Cuevas Rolando A RA Forero Adriana A Dhar Jayeeta J Ibsen Mikkel Søes MS Schmid-Burgk Jonathan Leo JL Schmidt Tobias T Ganapathiraju Madhavi K MK Fujita Takashi T Hartmann Rune R Barik Sailen S Hornung Veit V Coyne Carolyn B CB Sarkar Saumendra N SN
Immunity 20140612 6
Virus infection is sensed in the cytoplasm by retinoic acid-inducible gene I (RIG-I, also known as DDX58), which requires RNA and polyubiquitin binding to induce type I interferon (IFN) and activate cellular innate immunity. We show that the human IFN-inducible oligoadenylate synthetases-like (OASL) protein has antiviral activity and mediates RIG-I activation by mimicking polyubiquitin. Loss of OASL expression reduced RIG-I signaling and enhanced virus replication in human cells. Conversely, OAS ...[more]