Ontology highlight
ABSTRACT:
SUBMITTER: Fioret BA
PROVIDER: S-EPMC4101892 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Fioret Bryan A BA Heimfeld Jeremy D JD Paik David T DT Hatzopoulos Antonis K AK
Cell reports 20140704 1
Cardiac tissue undergoes renewal with low rates. Although resident stem cell populations have been identified to support cardiomyocyte turnover, the source of the cardiac stem cells and their niche remain elusive. Using Cre/Lox-based cell lineage tracing strategies, we discovered that labeling of endothelial cells in the adult heart yields progeny that have cardiac stem cell characteristics and express Gata4 and Sca1. Endothelial-derived cardiac progenitor cells were localized in the arterial co ...[more]