A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis.
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ABSTRACT:
SUBMITTER: Dhingra N
PROVIDER: S-EPMC4101909 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Publications
A possible role for IL-17A in establishing Th2 inflammation in murine models of atopic dermatitis.
Dhingra Nikhil N Guttman-Yassky Emma E
The Journal of investigative dermatology 20140801 8
Atopic dermatitis (AD) is associated with the effects of T helper type 2 (Th2) and Th22 cytokines. Recent studies, however, have also implicated Th17 in acute AD. Functional studies of Th2 and Th22 cytokines revealed their roles in generating molecular changes during AD; IL-17A's role, however, has yet to be defined. The report by Nakajima et al. (this issue) begins to define that role by demonstrating IL-17A's ability to induce Th2 inflammation in acute disease. ...[more]
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