Ontology highlight
ABSTRACT:
SUBMITTER: Poi MJ
PROVIDER: S-EPMC4102663 | biostudies-literature | 2015 Jul
REPOSITORIES: biostudies-literature
Poi Ming J MJ Knobloch Thomas J TJ Sears Marta T MT Warner Blake M BM Uhrig Lana K LK Weghorst Christopher M CM Li Junan J
Molecular carcinogenesis 20131202 7
The presence of RD(INK4/ARF) (RD) enhancer in the INK4-ARF locus provides a novel mechanism to simultaneously increase the transcription of p15(INK4b) (p15), p14ARF (p14), and p16(INK4a) (p16). While such upregulation can be repressed through interactions between RD and oncoproteins CDC6 and BMI1, little is known about the involvement of RD in cancer. In this study we investigated RD deletions in 30 squamous cell carcinoma of the head and neck (SCCHN) and the patient-matched High At-Risk Mucosa ...[more]