Dataset Information

Trends in gynecologic cancer mortality in East Asian regions.

ABSTRACT:

Objective

To evaluate uterine and ovarian cancer mortality trends in East Asian countries.

Methods

For three Asian countries and one region (Japan, Korea, Singapore, and Hong Kong), we extracted number of deaths for each year from the World Health Organization (WHO) mortality database, focusing on women ?20 years old. The WHO population data were used to estimate person-years at risk for women. The annual age-standardized, truncated rates were evaluated for four age groups. We also compared age-specific mortality rates during three calendar periods (1979 to 1988, 1989 to 1998, and 1999 to 2010). Joinpoint regression was used to determine secular trends in mortality. To obtain cervical and uterine corpus cancer mortality rates in Korea, we re-allocated the cases with uterine cancer of unspecified subsite according to the proportion in the National Cancer Incidence Databases.

Results

Overall, uterine cancer mortality has decreased in each of the Asian regions. In Korea, corrected cervical cancer mortality has declined since 1993, at an annual percentage change (APC) of -4.8% (95% confidence interval [CI], -5.3 to -4.4). On the other hand, corrected uterine corpus cancer mortality has abruptly increased since 1995 (APC, 6.7; 95% CI, 5.4 to 8.0). Ovarian cancer mortality was stable, except in Korea, where mortality rates steadily increased at an APC of 6.2% (95% CI, 3.4 to 9.0) during 1995 to 2000, and subsequently stabilized.

Conclusion

Although uterine cancer mortality rates are declining in East Asia, additional effort is warranted to reduce the burden of gynecologic cancer in the future, through the implementation of early detection programs and the use of optimal therapeutic strategies.

SUBMITTER: Lee JY

PROVIDER: S-EPMC4102735 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Trends in gynecologic cancer mortality in East Asian regions.

Lee Jung-Yun JY Kim Eun-Yang EY Jung Kyu-Won KW Shin Aesun A Chan Karen K L KK Aoki Daisuke D Kim Jae-Weon JW Low Jeffrey J H JJ Won Young-Joo YJ

Journal of gynecologic oncology 20140703 3

<h4>Objective</h4>To evaluate uterine and ovarian cancer mortality trends in East Asian countries.<h4>Methods</h4>For three Asian countries and one region (Japan, Korea, Singapore, and Hong Kong), we extracted number of deaths for each year from the World Health Organization (WHO) mortality database, focusing on women ≥20 years old. The WHO population data were used to estimate person-years at risk for women. The annual age-standardized, truncated rates were evaluated for four age groups. We als ...[more]

PMID: 25045429

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Project description:BackgroundAmidst the rising breast cancer burden in Asia, we aim to predict the future mortality risk due to breast cancer and identify the risk-attributable deaths for breast cancer among East and South Asian countries.MethodsWe used country-level data to predict the trends in the next decade relating to female breast cancer mortality by employing data from 1990 to 2019 from the Global Burden of Disease 2019 study. We used the stochastic mortality modeling and prediction techniques to forecast the age-specific and risk-attributable breast cancer mortality trends at the regional and national levels of East and South Asia.ResultsThe number of deaths caused by the breast cancer is predicted to increase in East and South Asian countries in the next decade (2020-2030). Age-standardized death rate (ASDR) of breast cancer is predicted to increase by 7.0% from 9.20/100,000 (95% CI: 6.04-12.12) in 1990 to 9.88/100,000 (95% CI: 7.12-11.4) in 2030 in East Asia, and about 35% increase from 13.4/100,000 (95% CI: 9.21-16.02) in 1990 to 18.1/100,000 (95% CI: 13.23-21.10) in 2030 in South Asia. At the national level, the highest percent change in ASDR between 1990 and 2030 was reported in Pakistan (a 62% increase) and Nepal (a 47% increase). The highest percent change in breast cancer mortality between 2020 and 2030 for females of age group 80-84 years was observed in Pakistan [21.6, (95% CI, 20.6-94.7)], followed by Afghanistan [13.3 (4.0-80.8)], and Nepal [36.6 (11.1-125.7)] as compared to the other countries. In the females of aged 50-80 years, the predicted death rates were associated with high body mass index, high-fasting plasma glucose, and diet high in red meat, across the majority of countries under study. Furthermore, reductions in percent change in mortality rates occurred in several countries with increases in sociodemographic index (SDI), notably across high SDI countries.ConclusionBreast cancer mortality risk varies substantially across East and South Asian countries with higher mortality risk in low/middle SDI countries. Early detection using screening, awareness among females and health workers, and cost-effective and timely treatment of patients with breast cancer is vital in stemming the tide of breast cancer in the next decade.

Dataset Information

Trends in gynecologic cancer mortality in East Asian regions.

Objective

Methods

Results

Conclusion

Publications

Trends in gynecologic cancer mortality in East Asian regions.

Similar Datasets

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