Ontology highlight
ABSTRACT:
SUBMITTER: Abraham J
PROVIDER: S-EPMC4102765 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Abraham Jinu J Nuñez-Álvarez Yaiza Y Hettmer Simone S Carrió Elvira E Chen Hung-I Harry HI Nishijo Koichi K Huang Elaine T ET Prajapati Suresh I SI Walker Robert L RL Davis Sean S Rebeles Jennifer J Wiebush Hunter H McCleish Amanda T AT Hampton Sheila T ST Bjornson Christopher R R CR Brack Andrew S AS Wagers Amy J AJ Rando Thomas A TA Capecchi Mario R MR Marini Frank C FC Ehler Benjamin R BR Zarzabal Lee Ann LA Goros Martin W MW Michalek Joel E JE Meltzer Paul S PS Langenau David M DM LeGallo Robin D RD Mansoor Atiya A Chen Yidong Y Suelves Mònica M Rubin Brian P BP Keller Charles C
Genes & development 20140701 14
Lineage or cell of origin of cancers is often unknown and thus is not a consideration in therapeutic approaches. Alveolar rhabdomyosarcoma (aRMS) is an aggressive childhood cancer for which the cell of origin remains debated. We used conditional genetic mouse models of aRMS to activate the pathognomonic Pax3:Foxo1 fusion oncogene and inactivate p53 in several stages of prenatal and postnatal muscle development. We reveal that lineage of origin significantly influences tumor histomorphology and s ...[more]