Ontology highlight
ABSTRACT:
SUBMITTER: Shevtsov MA
PROVIDER: S-EPMC4102795 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Shevtsov Maxim A MA Komarova Elena Y EY Meshalkina Darya A DA Bychkova Natalia V NV Aksenov Nikolai D ND Abkin Sergey V SV Margulis Boris A BA Guzhova Irina V IV
Oncotarget 20140501 10
Hsp70 chaperone is known to stimulate anti-tumour immunity in a variety of cancer models. Here we demonstrated that the addition of purified recombinant Hsp70 to the culture medium facilitated cancer cell cytolysis by lymphocytes. Importantly, exogenous Hsp70 triggered secretion of the intracellular Hsp70 to a cell surface and extracellular milieu, which played a role in cytolysis because down-regulation of the endogenous Hsp70 reduced both its presence at the cell surface and the lymphocyte-med ...[more]