Effect on cardiovascular risk of high density lipoprotein targeted drug treatments niacin, fibrates, and CETP inhibitors: meta-analysis of randomised controlled trials including 117,411 patients.

ABSTRACT:

Objective

To investigate the effects on cardiovascular outcomes of drug interventions that increase high density lipoprotein levels.

Design

Meta-analysis.

Studies reviewed

Therapeutic benefit of niacin, fibrates, and cholesteryl ester transfer protein (CETP) inhibitors on cardiovascular events (all cause mortality, coronary heart disease mortality, non-fatal myocardial infarction, and stroke).

Results

117,411 patients were randomised in a total of 39 trials. All interventions increased the levels of high density lipoprotein cholesterol. No significant effect was seen on all cause mortality for niacin (odds ratio 1.03, 95% confidence interval 0.92 to 1.15, P=0.59), fibrates (0.98, 0.89 to 1.08, P=0.66), or CETP inhibitors (1.16, 0.93 to 1.44, P=0.19); on coronar

SUBMITTER: Keene D 

PROVIDER: S-EPMC4103514 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature