Ontology highlight
ABSTRACT:
SUBMITTER: Marciano DC
PROVIDER: S-EPMC4103627 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Marciano David C DC Lua Rhonald C RC Katsonis Panagiotis P Amin Shivas R SR Herman Christophe C Lichtarge Olivier O
Cell reports 20140605 6
Natural selection for specific functions places limits upon the amino acid substitutions a protein can accept. Mechanisms that expand the range of tolerable amino acid substitutions include chaperones that can rescue destabilized proteins and additional stability-enhancing substitutions. Here, we present an alternative mechanism that is simple and uses a frequently encountered network motif. Computational and experimental evidence shows that the self-correcting, negative-feedback gene regulation ...[more]