Dataset Information

Serum vitamin D, vitamin D binding protein, and risk of colorectal cancer.

ABSTRACT:

Background

We previously reported a positive association between serum 25-hydroxyvitamin D (25(OH)D) and colorectal cancer risk. To further elucidate this association, we examined the molar ratio of 25(OH)D to vitamin D binding protein (DBP), the primary 25(OH)D transport protein, and whether DBP modified the association between 25(OH)D and colorectal cancer risk.

Methods

In a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, controls were 1?1 matched to 416 colorectal cancer cases based on age and date of blood collection. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for quartiles of 25(OH)D, DBP, and the molar ratio of 25(OH)D:DBP, a proxy for free, unbound circulating 25(OH)D.

Results

Comparing highest to lowest quartiles, DBP was not associated with colorectal cancer risk (OR?=?0.91; 95% CI: 0.58, 1.42, p for trend ?=?0.58); however, a positive risk association was observed for the molar ratio of 25(OH)D:DBP (OR?=?1.44; 95% CI: 0.92, 2.26, p for trend ?=?0.04). In stratified analyses, the positive association between 25(OH)D and colorectal cancer was stronger among men with DBP levels above the median (OR?=?1.89; 95% CI: 1.07, 3.36, p for trend ?=?0.01) than below the median (OR?=?1.20; 95% CI: 0.68, 2.12, p for trend ?=?0.87), although the interaction was not statistically significant (p for interaction ?=?0.24).

Conclusion

Circulating DBP may influence the association between 25(OH)D and colorectal cancer in male smokers, with the suggestion of a stronger positive association in men with higher DBP concentrations. This finding should be examined in other populations, especially those that include women and non-smokers.

SUBMITTER: Anic GM

PROVIDER: S-EPMC4103858 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Serum vitamin D, vitamin D binding protein, and risk of colorectal cancer.

Anic Gabriella M GM Weinstein Stephanie J SJ Mondul Alison M AM Männistö Satu S Albanes Demetrius D

PloS one 20140718 7

<h4>Background</h4>We previously reported a positive association between serum 25-hydroxyvitamin D (25(OH)D) and colorectal cancer risk. To further elucidate this association, we examined the molar ratio of 25(OH)D to vitamin D binding protein (DBP), the primary 25(OH)D transport protein, and whether DBP modified the association between 25(OH)D and colorectal cancer risk.<h4>Methods</h4>In a nested case-control study within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, controls we ...[more]

PMID: 25036524

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Project description:BackgroundHigh circulating levels of vitamin D (25(OH)D) are suggested to reduce the risk of urinary bladder cancer (BC), but the evidence is weak, and several studies lack sufficient adjustment for potential confounders (e.g., smoking, body mass index (BMI), and physical activity). Moreover, few studies have investigated the role of vitamin D-binding protein (DBP) in this context. We conducted a matched nested case-control study including 378 cases and 378 controls within the Norwegian population-based Janus cohort, using serum collected 5-41 years prior to diagnosis, to study 25(OH)D and BC risk, by taking circulating DBP into account.MethodsCox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), for 25(OH)D, DBP, and the molar ratio of 25(OH)D:DBP, an estimate of unbound (free) 25(OH)D levels. We adjusted for smoking (status and pack-years), BMI, physical activity, education and (mutually) for 25(OH)D and DBP. Restricted cubic splines were employed to examine nonlinear associations.ResultsHigh optimal levels of circulating 25(OH)D (≥100 nmol/L) (HR 0.35, 95% CI 0.19-0.64) were associated with decreased BC risk, when compared with insufficient concentrations (50-74 nmol/L). This association was less pronounced for optimal levels (75-99 nmol/L) (HR = 0.69, 95% CI 0.47-1.01). Moreover, estimated free 25(OH)D, was associated with decreased BC risk for molar ratio 17-21 (HR 0.66, 95% CI 0.44-0.97) and ≥22 (HR 0.50, 95% CI 0.29-0.82), compared to molar ratio 11-16. The HR function for BC risk was not linear, rather reversed u-shaped, with the highest HR at 62.5 nmol/L and 13.5 molar ratio, respectively.ConclusionHigh levels of total and estimated free 25(OH)D were associated with reduced risk of BC, compared with insufficient concentrations. DBP was not associated with BC risk. We did not observe any impact of DBP or any of the studied lifestyle factors on the association between 25(OH)D and BC.

Dataset Information

Serum vitamin D, vitamin D binding protein, and risk of colorectal cancer.

Background

Methods

Results

Conclusion

Publications

Serum vitamin D, vitamin D binding protein, and risk of colorectal cancer.

Similar Datasets

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