Ontology highlight
ABSTRACT:
SUBMITTER: Smoller JW
PROVIDER: S-EPMC4103972 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Smoller Jordan W JW Gallagher Patience J PJ Duncan Laramie E LE McGrath Lauren M LM Haddad Stephen A SA Holmes Avram J AJ Wolf Aaron B AB Hilker Sidney S Block Stefanie R SR Weill Sydney S Young Sarah S Choi Eun Young EY Rosenbaum Jerrold F JF Biederman Joseph J Faraone Stephen V SV Roffman Joshua L JL Manfro Gisele G GG Blaya Carolina C Hirshfeld-Becker Dina R DR Stein Murray B MB Van Ameringen Michael M Tolin David F DF Otto Michael W MW Pollack Mark H MH Simon Naomi M NM Buckner Randy L RL Ongür Dost D Cohen Bruce M BM
Biological psychiatry 20140118 11
<h4>Background</h4>Individuals with panic disorder (PD) exhibit a hypersensitivity to inhaled carbon dioxide, possibly reflecting a lowered threshold for sensing signals of suffocation. Animal studies have shown that carbon dioxide-mediated fear behavior depends on chemosensing of acidosis in the amygdala via the acid-sensing ion channel ASIC1a. We examined whether the human ortholog of the ASIC1a gene, ACCN2, is associated with the presence of PD and with amygdala structure and function.<h4>Met ...[more]