Ontology highlight
ABSTRACT:
SUBMITTER: Hunter RW
PROVIDER: S-EPMC4104029 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Chemistry & biology 20140701 7
AMPK is a sensor of cellular energy status and a promising target for drugs aimed at metabolic disorders. We have studied the selectivity and mechanism of a recently described activator, C2, and its cell-permeable prodrug, C13. C2 was a potent allosteric activator of α1-complexes that, like AMP, also protected against Thr172 dephosphorylation. Compared with AMP, C2 caused only partial allosteric activation of α2-complexes and failed to protect them against dephosphorylation. We show that both ef ...[more]