Ontology highlight
ABSTRACT:
SUBMITTER: Peters JP
PROVIDER: S-EPMC4104048 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Peters Justin P JP Mogil Lauren S LS McCauley Micah J MJ Williams Mark C MC Maher L James LJ
Biophysical journal 20140701 2
This work probes the mystery of what balance of forces creates the extraordinary mechanical stiffness of DNA to bending and twisting. Here we explore the relationship between base stacking, functional group occupancy of the DNA minor and major grooves, and DNA mechanical properties. We study double-helical DNA molecules substituting either inosine for guanosine or 2,6-diaminopurine for adenine. These DNA variants, respectively, remove or add an amino group from the DNA minor groove, with corresp ...[more]