Pleiotropy in complex traits: challenges and strategies.
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ABSTRACT:
SUBMITTER: Solovieff N
PROVIDER: S-EPMC4104202 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Publications
Pleiotropy in complex traits: challenges and strategies.
Solovieff Nadia N Cotsapas Chris C Lee Phil H PH Purcell Shaun M SM Smoller Jordan W JW
Nature reviews. Genetics 20130611 7
Genome-wide association studies have identified many variants that each affects multiple traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders, suggesting that pleiotropic effects on human complex traits may be widespread. However, systematic detection of such effects is challenging and requires new methodologies and frameworks for interpreting cross-phenotype results. In this Review, we discuss the evidence for pleiotropy in contemporary genetic mapping studies ...[more]
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