Ontology highlight
ABSTRACT:
SUBMITTER: Saha A
PROVIDER: S-EPMC4104231 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Saha Arindam A Connelly Stephen S Jiang Jingjing J Zhuang Shunhui S Amador Deron T DT Phan Tony T Pilz Renate B RB Boss Gerry R GR
Molecular cell 20140626 2
The phosphatidylinositol 3-kinase (PI3K)/Akt pathway integrates environmental clues to regulate cell growth and survival. We showed previously that depriving cells of a single essential amino acid rapidly and reversibly arrests purine synthesis. Here we demonstrate that amino acids via mammalian target of rapamycin 2 and IκB kinase regulate Akt activity and Akt association and phosphorylation of transketolase (TKT), a key enzyme of the nonoxidative pentose phosphate pathway (PPP). Akt phosphoryl ...[more]