Ontology highlight
ABSTRACT:
SUBMITTER: Bannon MJ
PROVIDER: S-EPMC4104338 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Bannon Michael J MJ Johnson Magen M MM Michelhaugh Sharon K SK Hartley Zachary J ZJ Halter Steven D SD David James A JA Kapatos Gregory G Schmidt Carl J CJ
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20140319 9
Chronic drug abuse, craving, and relapse are thought to be linked to long-lasting changes in neural gene expression arising through transcriptional and chromatin-related mechanisms. The key contributions of midbrain dopamine (DA)-synthesizing neurons throughout the addiction process provide a compelling rationale for determining the drug-induced molecular changes that occur in these cells. Yet our understanding of these processes remains rudimentary. The postmortem human brain constitutes a uniq ...[more]