Ontology highlight
ABSTRACT:
SUBMITTER: Sinha M
PROVIDER: S-EPMC4104429 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Sinha Manisha M Jang Young C YC Oh Juhyun J Khong Danika D Wu Elizabeth Y EY Manohar Rohan R Miller Christine C Regalado Samuel G SG Loffredo Francesco S FS Pancoast James R JR Hirshman Michael F MF Lebowitz Jessica J Shadrach Jennifer L JL Cerletti Massimiliano M Kim Mi-Jeong MJ Serwold Thomas T Goodyear Laurie J LJ Rosner Bernard B Lee Richard T RT Wagers Amy J AJ
Science (New York, N.Y.) 20140505 6184
Parabiosis experiments indicate that impaired regeneration in aged mice is reversible by exposure to a young circulation, suggesting that young blood contains humoral "rejuvenating" factors that can restore regenerative function. Here, we demonstrate that the circulating protein growth differentiation factor 11 (GDF11) is a rejuvenating factor for skeletal muscle. Supplementation of systemic GDF11 levels, which normally decline with age, by heterochronic parabiosis or systemic delivery of recomb ...[more]