Ontology highlight
ABSTRACT:
SUBMITTER: Schmitt K
PROVIDER: S-EPMC4104698 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Schmitt Kimberly K Guo Kejun K Algaier Malinda M Ruiz Autumn A Cheng Fang F Qiu Jianming J Wissing Silke S Santiago Mario L ML Stephens Edward B EB
Virology 20110825 1
The human apolipoprotein B mRNA editing enzyme catalytic peptide-like 3 (APOBEC3; A3) family of proteins (A3A-H) are known to restrict various retroviruses and retroelements, but the full complement of rhesus macaque A3 proteins remains unclear. We report the isolation and characterization of the hA3A homologue from rhesus macaques (rhA3A) and show that the rhesus macaque and human A3 genes are orthologous. RhA3A is expressed at high levels in activated CD4+ T cells, is widely expressed in macaq ...[more]