Ontology highlight
ABSTRACT:
SUBMITTER: Komatsu S
PROVIDER: S-EPMC4105593 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Komatsu Seiji S Nagai Yusuke Y Naruse Keiji K Kimata Yoshihiro Y
PloS one 20140721 7
Conventional self-assembling peptide hydrogels are effective as topical hemostatic agents. However, there is a possibility to harm living tissues due to their low pH. The aim of the present study was to demonstrate the efficacy of SPG-178, a neutral self-assembling peptide hydrogel, as a topical hemostatic agent. First, we measured the bleeding duration of incisions made on rat livers after application of SPG-178 (1.0% w/v), SPG-178 (1.5% w/v), RADA16 (1.0% w/v), and saline (n = 12/group). Secon ...[more]