Ontology highlight
ABSTRACT:
SUBMITTER: Zuccarino-Catania GV
PROVIDER: S-EPMC4105703 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Zuccarino-Catania Griselda V GV Sadanand Saheli S Weisel Florian J FJ Tomayko Mary M MM Meng Hailong H Kleinstein Steven H SH Good-Jacobson Kim L KL Shlomchik Mark J MJ
Nature immunology 20140601 7
Memory B cells (MBCs) are long-lived sources of rapid, isotype-switched secondary antibody-forming cell (AFC) responses. Whether MBCs homogeneously retain the ability to self-renew and terminally differentiate or if these functions are compartmentalized into MBC subsets has remained unclear. It has been suggested that antibody isotype controls MBC differentiation upon restimulation. Here we demonstrate that subcategorizing MBCs on the basis of their expression of CD80 and PD-L2, independently of ...[more]