Ontology highlight
ABSTRACT:
SUBMITTER: Kotsinas A
PROVIDER: S-EPMC4106421 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Kotsinas Athanassios A Papanagnou Panagiota P Evangelou Konstantinos K Trigas George C GC Kostourou Vassiliki V Townsend Paul P Gorgoulis Vassilis G VG
Frontiers in genetics 20140722
Alternative reading frame (ARF) is a tumor suppressor protein that senses oncogenic and other stressogenic signals. It can trigger p53-dependent and -independent responses with cell cycle arrest and apoptosis induction being the most prominent ones. Other ARF activities, particularly p53-independent ones, that could help in understanding cancer development and provide potential therapeutic exploitation are underrated. Although ARF is generally not expressed in normal tissues, it is essential for ...[more]