Ontology highlight
ABSTRACT:
SUBMITTER: Bajacan JE
PROVIDER: S-EPMC4106692 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Bajacan John Ernest Vallarta JE Hong In Seok IS Penning Trevor M TM Greenberg Marc M MM
Chemical research in toxicology 20140616 7
8-Oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) is a commonly formed DNA lesion that is useful as a biomarker for oxidative stress. Although methods for selective quantification of 8-oxodGuo exist, there is room for additional methods that are sensitive and utilize instrumentation that is widely available. We previously took advantage of the reported reactivity of 8-oxodGuo to develop a method for detecting the lesion by selectively covalently tagging it with a molecule equipped with a biotin la ...[more]